Laterality and coherence analysis of Laser Doppler Flowmetry signals in bilateral Nèi guān (内关 PC 6): a potential non-invasive method to assess microcirculatory changes of people in different ages * 双侧内关激光多普勒血流量侧性及其Coherence分析：一种 无创评价不同年龄人群微循环状态的潜在方法 *

作者：孙梦晓 来源：本站原创 点击：1726次 更新：1523845320

　　<p>WANG Guang-jun (王广军),&nbsp; TIAN Yu-ying (田宇瑛),&nbsp; JIA Shu-yong (贾术永),&nbsp; WANG Ze (王&nbsp; 泽), ZHANG Wei-bo (张维波)  </p><p><br/></p><p>Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, 100700, China（中国中医科学院针灸研究所，北京 100700，中国）</p><p><br/></p><p><strong>ARTICLE INFO</strong></p><p><br/></p><p>First author: WANG Guang-jun (1978-), male, associate professor.&nbsp;</p><p>Research field: acupuncture mechanism and alternative medicine.</p><p>E-mail: tjuwgj@gmail.com</p><p>Corresponding author: ZHANG Wei-bo (1961-), male, professor.</p><p>Research field: acupuncture mechanism and meridian research.</p><p>E-mail: 1507307638@qq.com</p><p>* Supported by the Fundamental Research Funds for the Central Public Welfare Research Institutes: ZZ070806,</p><p>National Natural Science Foundation of China: 81001553;</p><p>National Basic Research Program of China: 2015CB554502</p><p>Accepted on October 28, 2016</p><p><br/></p><p><strong>ABSTRACT</strong></p><p><br/></p><p style="text-align: justify;">Objective&nbsp; To investigate lateralization and Coherence analysis of blood perfusion in bilateral Nèiguān (内关 PC 6) in different ages. Methods&nbsp; Healthy volunteers (n=30) were placed in a temperature-controlled room as a resting state for 40 min. Then the blood perfusion of bilateral PC 6 were carried out using PeriFlux System 5000 for 15 minutes. Mean blood flux of every 5 minutes was calculated. Then the participants were divided into groups of young (n=18) and the old (n=12) as the boundary of 40 years, the asymmetry index and coherence value of bilateral PC 6 were analyzed in different group. Results&nbsp; The mean blood flow of the right PC 6 was significantly higher than the left PC 6 in three different epochs, the mean blood flow of right PC 6 vs left PC 6 is 9.74±3.36 vs 6.73±2.22 (t=5.9, P&lt;0.001), 9.83±3.63 vs 6.99±2.37 (t=5.11, P&lt;0.001) and 9.69±3.40 vs 6.77±2.32 (t=5.99, P&lt;0.001), respectively. Although the asymmetry index is higher in old group than in young group, there is no statistically significant age-related differences. Coherence analysis suggest that there is significant difference in frequency value corresponding to peak crest between young and old group. Conclusion&nbsp; The blood perfusion in right PC 6 is higher than left PC 6. Coherence analysis of laser Doppler flowmetry signals in bilateral PC 6 might provide a potential non-invasive method to assess microcirculatory changes in different ages.</p><p><br/></p><p><strong>KEY WORDS:</strong> acupoint; acupoint laterality; laser doppler blood flowmetry; Nèi guān (内关 PC 6); coherence analysis</p><p><br/></p><p><strong>ABSTRACT IN CHINESE</strong></p><p style="text-align: justify;">[摘 要] 目的：研究不同年龄人群双侧内关穴区激光多普勒血流量的侧性及其相干性。方法：共计30例健康受试者参与血流检测。受试者先在控制室温条件的房间中休息40 min，然后用PeriFlux System 5000记录受试者双侧内关血流15分钟，每5分钟为一时间段进行分析。受试者以40岁为界分成年轻组（n=18）和年长组（n=12），计算不同组间左右内关血流量的不平衡系数和Coherence值。结果：在三个时间段内，右侧内关平均血流量依次为9.74±3.36 PU、9.83±3.63 PU、9.69±3.40 PU，左侧内关平均血流量依次为 6.73±2.22PU、6.99±2.37PU 6.77±2.32PU，经检验左右差异均有显著性（均P&lt;0.01）。虽然不平衡系数年长组高于年轻组，但组间差异无统计学意义。Coherence分析结果提示，从0.5 Hz到1.5 Hz之间，其波峰对应的频率值组间存在显著差异。结论：右侧内关血流灌注值高于左侧内关，双侧内关激光多普勒血流量的Coherence分析可为不同年龄人群微循环状态的改变提供一种潜在的无创评价方法。</p><p style="text-align: justify;">[关键词] 穴位 穴位侧性 激光多普勒血流量 内关穴 Coherence分析</p><p><br/></p>