SHI Renyi , LIANG Yi , Du Junying , Fang Junfan

Abstract:  Bone cancer pain mostly due to lung cancer, breast cancer and prostate cancer caused by bone metastases, is a stubborn refractory pain. Now there are relevant research for pathological mechanism  of  bone  cancer  pain,  but  still  can  not  clear  its  specific  mechanism.  P2X  receptormediated purinergic signals in tumor growth, metastasis-related pathological mechanisms have a very  important  role,  but  also  involved  in  the  formation  and  maintenance  of  cancer  pain.  P2X receptor is a gated ion channel of adenosine triphosphate (ATP), which mainly includes 7 subtypes of P2X1-P2X7. Preliminary studies have shown that P2X3, P2X4, P2X6 and P2X7 receptors are involved in the development of bone cancer pain, and the related mechanisms exist difference. This review summarizes the mechanisms involved in the involvement of P2X receptors in the development and maintenance of bone cancer pain and further confirms that P2X receptors play a key role in bone cancer pain.

Key words: P2X receptor, bone tumor, pain , mechanism