ZHANG Yu-jia, LI Shuang,  YU Yueyue, HAN Junping, ZHAO Ye,  YANG Jinhua, CUI Jian-mei

（College of TCM, North China University of Science and Technology, Tangshan 063000)

Abstract: Objective: To explore the effects of acupuncture on the expression of Fibronection and CollagenⅠ in lung tissues of asthmatic rats. Methods: Thirty SPF male SD rats were randomly divided into normal control group, asthmatic  model  group  and  the  acupuncture  treatment  group,  with  10  rats  in  each  group. Groups were given accordingly interventions, HE staining was applied to observe the morphologic changes of lung tissues; the immunohistochemical method was applied to test the protein expression of Fibronectionand CollagenⅠ in lung tissue. Results: Acupuncture can effectively improve pathological changes of lung tissues in asthmatic rats. The expression of Fibronection and CollagenⅠ in lung tissue  of acupuncture group significantly  lower  than  asthmatic  group(F=32.408 ，P=0.000 ；F=15.861 ，P=0.000).  Conclusion:   Acupuncture could reduce the protein expression of Fibronection and CollagenⅠin lung tissues in asthmatic rats leading to airway remodeling.

Key words:  Acupuncture, asthmatic, Fibronection, CollagenⅠ