Shugan Tiaoshen needling method for postherpetic neuralgia：A randomized controlled trial
疏肝调神针刺法治疗带状疱疹后遗神经痛:一项随机对照临床试验

Yi-ling YANG (杨一玲)^a,b, Wei-xuan ZHAO (赵伟璇)^a, Jia-le LI (李嘉乐)^b, Wei-qiang CHEN (陈伟强)^b

^a Traditional Chinese Medicine Department of The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China（广东药科大学附属第一医院中医科, 广州510080, 中国）

^b Nursing College of Guangdong Pharmaceutical University, Guangzhou 510315, China （广东药科大学护理学院, 广州510315, 中国）

Abstract

Objective: To observe the efficacy of Shugan Tiaoshen (liver-soothing and mind-regulating) needling method in the treatment of patients with postherpetic neuralgia (PHN).

Methods: A total of 66 patients with PHN were randomly divided into acupuncture group and control group, 33 cases in each one, by the random number table method. The acupuncture group received Shugan Tiaoshen needling method plus gabapentin, whereas the control group received the oral administration of gabapentin and sham acupuncture. Numerical Rating Scale (NRS), State-Trait Anxiety Inventory (STAI) and Pittsburgh Sleep Quality Index (PSQI) were used to evaluate the pain condition, anxiety symptom and sleep quality. The effective rate and adverse events were also evaluated and recorded during the treatment.

Results: After eight weeks of treatment, the NRS scores of the two groups were significantly lower than those before treatment (P<0.05) at all time points, which were statistically significant difference between the groups (P<0.05). The scores of STAI and PSQI of the acupuncture group were significantly lower than the scores before treatment (P<0.05). The scores of STAI for anxiety symptom and PSQI of the acupuncture group were significantly lower than the control group (P<0.05), and the effective rate of the acupuncture group was significantly higher than that of the control group (P<0.05). The incidence of adverse reactions in the acupuncture group was significantly lower than that in the control group (P<0.05).

Conclusion: Shugan Tiaoshen needling method showed satisfactory efficacy in treating PHN, and could alleviate the pain, relieve the anxiety symptoms, promote sleep, and reduce the adverse reactions of gabapentin in patients with PHN.

【摘要】

目的：观察疏肝调神针刺法联合加巴喷丁治疗带状疱疹后遗神经痛的临床疗效。

方法：将66例带状疱疹后遗神经痛患者按随机数字表法分为针刺组和对照组，每组各33例。针刺组采用疏肝调神针刺法联合加巴喷丁治疗，对照组给予假针刺联合加巴喷丁治疗。采用疼痛数字评分（Numerical Rating Scale, NRS）对患者治疗前、首次治疗结束时、第2周治疗后、第4周治疗后、第8周治疗后的疼痛程度进行评定，观察两组患者治疗前及末次治疗后的状态-特质焦虑量表（State-Trait Anxiety Inventory, STAI）及匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index,PSQI）的评分变化，并比较两组有效率及不良反应发生率。

结果：经过8周治疗，两组患者各时点NRS评分均显著低于治疗前（P＜0.05），且在各时点组间比较差异有统计学意义（P＜0.05）。针刺组STAI与PSQI与治疗前比较明显降低(均P＜0.05)，针刺组STAI及PSQI评分降低程度高于对照组（P＜0.05）。针刺组有效率高于对照组(P＜0.05)。针刺组药物不良反应发生率低于对照组(P＜0.05)。

结论：疏肝调神针刺法治疗带状疱疹后遗神经痛具有较好的临床效果，可以缓解疼痛，改善个体焦虑症状，提升患者的睡眠质量以及降低口服药物的不良反应。