How to generate high-quality clinical evidence: Taking the study of acupuncture for chronic urticaria published in Annals of Internal Medicine as an example
高质量临床证据如何产生：以《内科学年鉴》发表的针灸治疗慢性荨麻疹研究为例

Ren-hong WAN（万仁洪）^a，Wei CAO（曹炜）^b，Zi-hao ZOU（邹子豪）^a，Shuai CHEN（陈帅）^a，Si-jue CHEN（陈思珏）^c，Hui ZHENG（郑晖）^a，Ying LI（李瑛）^a

^a Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China (成都中医药大学针灸推拿学院，成都611137，中国)

^b Chengdu Integrated TCM and Western Medicine Hospital, Chengdu 610021, China (成都市中西医结合医院，成都610021，中国)

Abstract

High-quality clinical evidence is the basis of evidence-based medicine practice. Acupuncture is the most widely used complementary and alternative medicine in the world. However, the improvement in the quality of acupuncture clinical research does not match the rapid increase in the number of acupuncture clinical research in recent years. At present, the number of high-quality acupuncture clinical research in the world remains low. Taking the trial of acupuncture for chronic spontaneous urticaria published in Annals of Internal Medicine as an example, this paper discusses the factors of producing high-quality clinical evidence of acupuncture from the aspects of selecting the topic of study, formulating the study method, designing the study plan, controlling the study process, writing the study report, and selecting the journal in the process of before, during, and after the research. It emphasizes the necessity to start from the benefit of global people’s health, take practical clinical problems as guidance, cleverly choose the research entry point, and conduct high-quality research with clinical value. After the accomplishment of the study, the results must be faithfully described, the scientific conclusions accurately sublimated, and appropriate scientific journals selected for publication..

【摘要】

高质量的临床证据是实践循证医学的基础。针灸是全球范围内应用最广泛的补充替代医学，然而针灸临床研究质量的提升幅度与近年来迅猛增长的针灸临床研究数量并不匹配，现阶段世界范围内高质量针灸临床研究的数量仍处于低位。本文以《内科学年鉴》发表的针灸治疗慢性自发性荨麻疹的临床研究为例，从研究开始前、研究进行时及研究完成后对研究选题确定、研究方法制定、研究方案设计、研究过程质控、研究报告撰写及选刊等方面探讨针灸临床高质量证据产生的要素。强调要切实从惠及全球民众健康出发，以实际临床问题为导向，巧妙选取研究切入点，做有临床价值的高质量研究。研究完成之后，要忠实描述研究结果，准确升华科学结论，选择合适的科技期刊进行发表。