WU Lijie, ZHANG Jji1, ZHANG Dan,  Y ANG Yanting, YANG Ling, ZHI Fangyuan, WU Lingxiang, XIE Chen, MA Xiaopeng 

(1 Shanghai University of Traditional Chinese Medicine, shanghai 201203; 2 Shanghai Institute of Acupuncture and Moxibustion, shanghai 200030)

Abstract:  Inflammatory bowel disease is a group of chronic non-specific intestinal inflammatory diseases, including Crohn's disease (CD) and ulcerative colitis (UC).  Inflammasome,  as a kind of macromolecular compound protein,plays an important role in the development of inflammation and the  innate  immunity  of  the  body.  NLRP3  plays  a  bidirectional  role  in  the  development  of inflammatory  bowel  disease  and  in  maintaining  intestinal  homeostasis.This  paper  reviews  the progress of NLRP3 inflammatory mediators in IBD and the possible mechanism of acupuncture and moxibustion, and provides a new idea for the clinical and mechanism research of acupuncture and moxibustion treatment of inflammatory bowel disease.

Key words:  Acupuncture and Moxibustion, NLRP3 Inflammasome;  Inflammatory Bowel Disease