KONG Ying, ZHOU Wei

（1 The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Heilongjiang Harbin 150001；2 The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Heilongjiang Harbin 150040）

Abstract:  Objective:  By  observing  the  BaiHui-QuBin  scalp-acupuncture  on  acute  cerebral hemorrhage in the rat model of brain tissue IL-6 protein expression, to study the acupuncture on the cerebral hemorrhage secondary brain injury after the neuro protective mechanisms in order to guide clinical practice.  Methods:  1.Totally 60 male wistar rats were randomly allocated into fourgroup: blank group(n=6),intracerebral hemorrhage controlgroup(n=18),acupuncture group(n=18),and  western  medicine  (pisacetam)  group(n=18).  2.The  rat  models  of  acute intracerebral hemorrhage  were  made. 3.The  acupuncture  point:  BaiHui  point  to  QuBin  point, which can penetrate three regions of the cupula and forehead and temple.4.The Berderson neural deficit  scores  were  tested  at  three  time  points(6h,2d,7d  after  hemorrhage  model establishment)before the r-at models were killed, then the brains were removed and index were detected. 5.The average gray scale of Interleukin-6 protein expressio-n by immunohistoc-hemical method were checked,the morphologic cha-nge on light microscope was observed. 6. Statistical treatment was made.  Results:  1.The results of the neurologic deficit score of the acupunct-ure group  is  better  than  intracerebral  hemorrhage  group  and  western  medicine  group  at  2  days. Acupuncture  group  and  western  medicine  group  were  better  than  those  in  intracerebral hemorrhage  group  at  7  days.  2.The  results  of  masculine  cell  in  the  average  gray  scale  of Interleukin-6  in  untreated  control  group  is  different  from  intracerebra-l  hemorrhage  gro-up (ICH).In 2 days,the average gray scale of Interleukin-6 in acupu-ncture group is lower than those in intracerebral hemorrhage group.T -here was also difference between acupuncture group and western  medi-cine  group.  Acupuncture  group  and  western  medicine  group  were  low-er  than those in intracerebral hemorrhage group,and there was differe-nce between acupuncture group and  western medicine group  in  7 days.3.The results of the brain pathological change in acupuncture group and western medicine group is different from those in intracerebral hemorrhage group. Conclusion:1.BaiHui-QuBin acupuncture can obviously raise the B-erderson neural deficit scores,  and  have  the  benefit  of  improvement  of  extremity  function  after  intracerebral hemorrhage.2.  Study  showed  that  acute  phase  of  cerebral  hemorrhage,  BaiHui-QuBin  scalpacupuncture therapy can be reduced IL-6 protein expression, reduce the inflammatory response after cerebral hemorrhage caused by the extent of secondary brain injury, ischemic brain tissue in order to improve status and the protection of hypoxic injury in neurons.

Key words: Acute intracerebral hemorrhage, Acupuncture, BaiHui-QuBin, Interleukin-6