SHI Yin, WU Huangan, SHANG Haixia, ZHOU Jing, LI Tao

(1 Shanghai University of Traditional Chinese Medicine, Shanghai 201203; 2 Shanghai Institute of Acupuncture-Moxibustion and Meridian, Shanghai200030)

Abstract: Crohn's disease is a chronic and recurrent inflammatory bowel disease involving the whole layer of digestive tract. One of its key factors is the increase permeability of intestinal epithelial barrier resulting from  abnormality  of  tight  junction  pathway  of  TNF-α-induced  NF-κB-MLCK  in  colonic  epithelium.  Our previous studies have shown that herbs-partition moxibustion is an effective treatment for Crohn's disease. This study aims at observing effect of herbs-partition moxibustion in reducing permeability of intestinal epithelial barrier by regulating  TNF-α/NF-κB-MLCKtight junction pathway to restore intestinal epithelial barrier and inhibit inflammation in Crohn's disease.

Key  words：Crohn's  disease,  herbs-partition  moxibustion,  TNF-α/NF-κB-MLCK,  tight  junction pathway, vitro study