Liu Yamin, Sun Zhongren  ^✉

(Heilongjiang University of Traditional Chinese Medicine, Harbin150040, Heilongjiang, China)

Abstract: With the increasing pressure of modern life, young and middle-aged women, both suffering from thyroid nodules, breast hyperplasia, Leiomyoma, one of the two or three diseases ,besides ,the number of patients is constantly increasing. Hypothalamo - pituitary - gonadal axis (HPGA) changes have a correlation with the incidence of thyroid nodules, breast hyperplasia, Leiomyoma .In recent years, many scholars study the network regulation of reproductive function by acupuncture from the overall gene-cell-gene level.Acupuncture treatment of reproductive and endocrine diseases have achieved a certain effect.Acupuncture and moxibustion on the gonadal axis from the center to the gonadal regulation mechanism of experimental research has made many new advance.Acupuncture on the (HPGA)  has a significant regulatory role.Its role may be related to acupuncture regulating hypothalamic-pituitary β-endorphin level and promoting the expression of c-fos and other third messengers.However, the existing studies are scattered and repetitive, and there is a lack of large-scale and serialized research on comprehensive multidisciplinary cooperation.There are many mechanisms are not clear, pending further study and research.This article discusses the relationship between the hypothalamic pituitary gland axis and thyroid nodules, breast hyperplasia and uterine fibroids from the perspective of holistic perspective.From a macro point of view, the occurrence of such diseases may be the body's internal environment suitable for their growth, proliferation,This change in the internal environment, of course, appears to gasification disorders，If you can adjust its abnormal gasification, so that the body's gasification activity back to the original state of order, Then eliminate the nodules within the environment。The overall regulation is the advantage of acupuncture.Acupuncture can adjust the endocrine system function in a bidirectional, benign and whole way according to the pathological state of human body and other related factors to achieve the stability and balance of the body and maintaining the balance of internal and external environment. The overall regulation is the advantage of acupuncture.Acupuncture treatment can promote blood circulation, Endometriosis, improve local blood circulation, strengthen the local tissue metabolism, in order to facilitate atrophy and absorption of nodules. Acupuncture can play a role in the treatment of endocrine system diseases and gynecological diseases.

Key words: Acupuncture, Hypothalamo-pituitary-gonadal axis (HPGA), Thyroid nodules, breast hyperplasia, Leiomyoma