Abstract  

The structure and function of acupoints have been paid more attention, especially the specific effects treating certain kind of disease. Recent clinic studies only confirmed if the effect of the selected acupoints treating the disease was better than the sham or placebo control. But they did not show any specific effect between acupoints and the related disease or target organs. However the specific functions of acupoints is considered as the kernel of Chinese acupuncture theory. The speech focuses on the distribustion of the sensitized acupoints induced by the gastric mucosa injury and the local biochemistry changes of mast cells, nociceptive neuropeptides calcitonin gene-related peptide(CGRP) and substance P (SP), and allergic substances such as histamine (HA) and serotonin (5-HT). The specific effect of acupoints was related to the target organ and the sensitized acupoint reflects the function of the target organ. The acupoints also has general effect besides the specific effect. The general effects are induced by the brain-skin axis which is distributed in the skin and demonstrated by the activation of local HPA, neuropeptide and cytokines.